Welcome to GTBAdb

Guilt By Association Analysis

TwoGenePlot

Correlation analysis between two elements

GTBA

Gene annotation with GTBA

panGTBA

Perform GTBA with multiple tissue types

multiGTBA

Perform GTBA with multiple genes

sincorBatch

Batch correlation analysis in single tissue

pancorBatch

Batch correlation analysis in multiple tissue


                                  

                                

                              

                            

                          

                        

                      

                    

                  

                

                

                

                  

                    

                      

                        

                          Guilt By Association Analysis
                        

                      

                    

                  

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  
                  
                  

                    

                      

                        

                          
                            
                            Step1:first gene/gene set
                          
                        

                      

                      

                        

                        

                          

                            
                            

                              

                                

                                  

                                    

                                      

                                        Gene sets:
                                      

                                    

                                    

                                      Gene sets were used to evaluate gene set score in tissue types by ssgsea method.
                                      

                                      Gene set included are: Hallmark gene setsm, KEGG gene sets,Reactome Pathway gene sets, WikiPathways gene sets,GPSA gene sets
                                      

                                      

                                      GPSA gene sets were used to evaluate gene set score in tissue types by ssGPSA method.
                                      

                                      GPSA gene sets were derived from GPSAdb(http://guotosky.vip:13838/GPSA/).
                                      

                                      ssGPSA is a method from GPSAdb to perform double gene set variation analysis using ssgsea method.
                                    

                                  

                                

                              

                            

                            
                          

                        

                        

                          
                          

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                          

                        

                        

                        

                          
                          

                            
                            
                          

                        

                        (ensembl id is also supported)
                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step2:Second gene/gene set
                          
                        

                      

                      

                        

                        

                          
                          

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                          

                        

                        

                        

                          
                          

                            
                            
                          

                        

                        (ensembl id is also supported)
                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step3: Choose datasource and method
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                      

                    

                  

                

                

                  

                    

                      

                        

                          
                            
                            pancorPlot
                          
                        

                      

                      

                        

                          
                          
    
                            
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                                        Plot introduction:
                                      

                                    

                                    

                                      Gene expression data was exracted from the selected datasource,
                                      

                                      The the data was then splited into subtypes and correlation analysis was performed using r function cor.test()
                                      

                                      Correlation results were then summarised into a data.frame which was shown in corTable panel.
                                      

                                      The x axis of pancorPlot is -log10(p value) and y axis is correlation coefficient.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Plot adjustment:
                                      

                                    

                                    

                                      Change genes, datasource, correlation methods, the plot changes accordingly and automatically.
                                      

                                      Clikc the cog button at the up-left corner of this panel to change point label and point shape
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Note:
                                      

                                    

                                    

                                      Plots in GTBAdb can be customized if a cog button exsists at the up-left corner of that plot.
                                      

                                      Plots in GTBAdb can be downloaded in three file types: PDF,SVG,JPEG. Choose whatever suitable
                                    

                                  

                                

                              

                            

                            
                          

                        

                        
                        

                          

                            
                            

                              

                                
                                
                                
                              

                            

                            
                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            corTable(Click rows to change)
                          
                        

                      

                      

                        

                          

                            
                            

                              

                                

                                  

                                    

                                      

                                        Data calculation:
                                      

                                    

                                    

                                      Gene expression data was exracted from the selected datasource,
                                      

                                      The the data was then splited into subtypes and correlation analysis was performed using r function cor.test()
                                      

                                      Correlation results were then summarised into a data.frame which was shown in this panel.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Click rows to change:
                                      

                                    

                                    

                                      If usres are interested in correlation plot in a single subtype,
                                      

                                      Click rows then correlation plot in that subtype will show in sincorPlot panel.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Note:
                                      

                                    

                                    
Tables in GTBAdb are clickable, feel free to try.

                                  

                                

                              

                            

                            
                          

                        

                        

                        

                        
                        

                        

                          

                            
                            

                              

                                
                              

                            

                            
                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            sincorPlot
                          
                        

                      

                      

                        

                          
                          
    
                            
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                                        Plot introduction:
                                      

                                    

                                    

                                      Gene expression data was exracted from the selected datasource and the selected subtype,
                                      

                                      Correlation analysis was performed using r function cor.test()
                                      

                                      The x axis of sincorPlot is the expression of first gene and and y axis is that of second gene.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Plot adjustment:
                                      

                                    

                                    
Change rug,point,line colors by clicking the cog button at the up-left corner of this plot.

                                  

                                

                              

                            

                            
                          

                        

                        
                        

                          

                            
                            

                              

                                
                                
                                
                              

                            

                            
                          

                        

                      

                    

                  

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  

                    

                      

                        

                          
                            
                            GTBA analysis
                          
                        

                      

                      

                        

                        

                        
                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step1:single gene/gene set
                          
                        

                      

                      

                        

                        

                          
                          

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                          

                        

                        

                        

                          
                          

                            
                            
                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step2: Choose datasource and method
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step3: Choose gene sets
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        
                      

                    

                  

                

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  

                    

                      

                        

                          
                            
                            panGTBA analysis
                          
                        

                      

                      

                        

                          

                            

                              

                                GTBA analysis in multiple subtypes
                              

                            

                            

                              Choose a single gene, and a datasource
                              

                              panGTBA performs GTBA analysis across all subtypes in that datasource
                            

                          

                        

                        

                          

                            

                              

                                Before you start:
                              

                            

                            

                              It is ranther time-consuming to perform panGTBA analysis
                              

                              It takes about 2 minutes to finish
                              

                              Please Wait
                              

                              Do not leave, if you really want to, TwoGenePlot panel is a place to go.
                              

                              GTBAdb will take you back when panGTBA finishes.
                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step1:single gene/gene set
                          
                        

                      

                      

                        

                        

                          
                          

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                          

                        

                        

                        

                          
                          

                            
                            
                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step2: Choose datasource and method
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step3: Choose gene sets
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        
                        
                      

                    

                  

                

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  

                    

                      

                        

                          
                            
                            multiGTBA analysis
                          
                        

                      

                      

                        

                          

                            

                              

                                GTBA analysis with multiple genes
                              

                            

                            

                              mutiGTBA performs GTBA analysis with multiple genes simultaneously,
                              

                              It helps to explore the function similarity and difference among a list of genes,
                            

                          

                        

                        

                          

                            

                              

                                Before you start:
                              

                            

                            

                              It takes about 1 gene per 3 seconds to perform
                              

                              Please Wait
                              

                              Do not leave, watching the progress bar updates will make you happy.
                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step1:genes you are interested
                          
                        

                      

                      

                        

                          

                            
                            

                              

                                

                                  

                                    

                                      

                                        Paste or upload:
                                      

                                    

                                    

                                      multiGTBA performs GTBA on multiple genes.Users can paste or upload a list of interested genes to explore their funtions and relations
                                      

                                      

                                      For example, m6A related genes, genes from a specific gene set, TFs and their targets, miRNAs and their targets.
                                      

                                      

                                      If you are sure what to paste or upload, click the example button to see examples, then click Run button to explore.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Note:
                                      

                                    

                                    

                                      The number of genes should be 2 to 30
                                      

                                      When miRNA exsists, do not choose GTEx or CCLE database
                                    

                                  

                                

                              

                            

                            
                          

                        

                        

                        

                          

                            
                            

                              
                            

                          

                        

                        List of Names:
                        
                        
                        

                        

                        

                          
                          
                        

                        

                        

                          

                            
                            

                              
                            

                          

                        

                        Upload a one column file:
                        
                        
                        

                        

                        

                          
                          

                            
                            
                          

                          

                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step2: Choose datasource and method
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step3: Choose gene sets
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        
                        
                      

                    

                  

                

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  

                    

                      

                        

                          
                            
                            sincorBatch analysis
                          
                        

                      

                      

                        

                          

                            

                              

                                Batch correlation analysis in single tissue type
                              

                            

                            

                              GTBA analysis is based on sincorBatch analysis
                              which calculates correlation between input gene with all protein coding genes to annotate genes in a  Guit By Association method
                              

                              Meanwhile,sincorBatch supports correlation calculation between other types of genes as listed in step2
                              

                              This helps users to explore gene functions in different relationships, like TF-targets, miRNA-targets,Pathway-members.
                              

                              Note: when miRNA is chosen, either in step1 or setp2, miRNA targets prediction will be performed automatically.
                            

                          

                        

                        

                          

                            

                              

                                Before you start:
                              

                            

                            

                              It takes about  15 seconds to finish
                              

                              Please Wait
                              

                              Do not leave, it's not worth it.
                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step1:single gene/gene set
                          
                        

                      

                      

                        

                        

                          
                          

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                          

                        

                        

                        

                          
                          

                            
                            
                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step2:choose correlation gene type
                          
                        

                      

                      

                        

                          

                            
                            

                              

                                

                                  

                                    

                                      

                                        Protein coding genes:
                                      

                                    

                                    
Genes defined as protein coding genes in GTF

                                  

                                

                                

                                  

                                    

                                      

                                        miRNA:
                                      

                                    

                                    
miRNAs detected in TCGA project.

                                  

                                

                                

                                  

                                    

                                      

                                        Transcription Factor:
                                      

                                    

                                    

                                      Gene defined as TFs are listed here:
                                      

                                      http://bioinfo.life.hust.edu.cn/HumanTFDB/#!/download
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Noncoding genes:
                                      

                                    

                                    
Genes defined as none coding genes in GTF

                                  

                                

                                

                                  

                                    

                                      

                                        Gene sets:
                                      

                                    

                                    

                                      Gene sets were used to evaluate gene set score in tissue types by ssgsea method.
                                      

                                      Gene set included are: Hallmark gene setsm, KEGG gene sets,Reactome Pathway gene sets, WikiPathways gene sets,Immune infiltration gene sets.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        GPSA double gene sets:
                                      

                                    

                                    

                                      GPSA gene sets were used to evaluate gene set score in tissue types by ssGPSA method.
                                      

                                      GPSA gene sets were derived from GPSAdb(http://guotosky.vip:13838/GPSA/).
                                      

                                      ssGPSA is a method from GPSAdb to perform double gene set variation analysis using ssgsea method.
                                    

                                  

                                

                              

                            

                            
                          

                        

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step3: Choose datasource and method
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        
                      

                    

                  

                  

                    

                      

                        

                      

                    

                  

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  

                    

                      

                        

                          
                            
                            pancorBatch analysis
                          
                        

                      

                      

                        

                          

                            

                              

                                Perform sincorBatch analysis in multiple subtypes
                              

                            

                            

                              While sincorBatch analysis finds which gene correlates with the input gene most in single tissue type
                              

                              pancorBatch analysis finds which gene correlates most in pantissue type.
                            

                          

                        

                        

                          

                            

                              

                                Before you start:
                              

                            

                            

                              It takes about 60 seconds to finish
                              

                              Please Wait
                              

                              Do not leave. If you do, it will still switch to pancorBatch panel when it finishes.
                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step1:single gene/gene set
                          
                        

                      

                      

                        

                        

                          
                          

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                            

                              
                              

                                
                                
                              

                            

                          

                        

                        

                        

                          
                          

                            
                            
                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step2:choose correlation gene type
                          
                        

                      

                      

                        

                          

                            
                            

                              

                                

                                  

                                    

                                      

                                        Protein coding genes:
                                      

                                    

                                    
Genes defined as protein coding genes in GTF

                                  

                                

                                

                                  

                                    

                                      

                                        miRNA:
                                      

                                    

                                    
miRNAs detected in TCGA project.

                                  

                                

                                

                                  

                                    

                                      

                                        Transcription Factor:
                                      

                                    

                                    

                                      Gene defined as TFs as listed here:
                                      

                                      http://bioinfo.life.hust.edu.cn/HumanTFDB/#!/download
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        Noncoding genes:
                                      

                                    

                                    
Genes defined as none coding genes in GTF

                                  

                                

                                

                                  

                                    

                                      

                                        Gene sets:
                                      

                                    

                                    

                                      Gene sets were used to evaluate gene set score in tissue types by ssgsea method.
                                      

                                      Gene set included are: Hallmark gene setsm, KEGG gene sets,Reactome Pathway gene sets, WikiPathways gene sets,Immune infiltration gene sets.
                                    

                                  

                                

                                

                                  

                                    

                                      

                                        GPSA double gene sets:
                                      

                                    

                                    

                                      GPSA gene sets were used to evaluate gene set score in tissue types by ssGPSA method.
                                      

                                      GPSA gene sets were derived from GPSAdb(http://guotosky.vip:13838/GPSA/).
                                      

                                      ssGPSA is a method from GPSAdb to perform double gene set variation analysis using ssgsea method.
                                    

                                  

                                

                              

                            

                            
                          

                        

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
                            
                            Step3: Choose datasource and method
                          
                        

                      

                      

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        

                          
                          

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                            

                              
                              

                                
                                
                              

                            

                            

                          

                        

                        
                        
                      

                    

                  

                

                

              

            

          

        
      

      

        
          

            
            
            

              

                

                  

                    

                      

                        
                        

                          

                            

                              

                                

                                  

                                    

                                      

                                        

                                          4
                                        

                                        
4 different datasources

                                      

                                      

                                        
                                      

                                    

                                  

                                

                              

                              

                                

                                  

                                    

                                      

                                        

                                          6
                                        

                                        
6 tools to explore your genes

                                      

                                      

                                        
                                      

                                    

                                  

                                

                              

                              

                                

                                  

                                    

                                      

                                        

                                          86
                                        

                                        
86 tissue subtypes included

                                      

                                      

                                        
                                      

                                    

                                  

                                

                              

                            

                            

                              

                                

                                  

                                    

                                      

                                        

                                          20,000+
                                        

                                        
20,000+ samples in total

                                      

                                      

                                        
                                      

                                    

                                  

                                

                              

                              

                                

                                  

                                    

                                      

                                        

                                          30,000+
                                        

                                        
30,000+ genes to explore, miRNA included

                                      

                                      

                                        
                                      

                                    

                                  

                                

                              

                              

                                

                                  

                                    

                                      

                                        

                                          16,000,000,000+
                                        

                                        
16,000,000,000+ plots to download